Computational epigenomics: challenges and opportunities

Computational epigenomics: challenges and opportunities

Citation: Robinson MD and Pelizzola M (2015) Computational epigenomics: challenges and opportunities. The field of epigenetics is undoubtedly attracting immense interest with countless studies in various areas of investigation; (see Rivera and Ren, 2013) for a review on the state of the art for human epigenomics. From the computational point of view and the characteristics of the generated data...

Sperm epigenomics: challenges and opportunities

Sperm is a highly differentiated cell type whose function is to deliver a haploid genome to the oocyte. The sperm "epigenomes" were traditionally considered to be insignificant - the sperm is transcriptionally inactive, its genome is packaged in sperm-specific protamine toroids instead of nucleosomes, and its DNA methylation profile is erased immediately post-fertilization. Yet, in recent years...

Islam; Challenges and Opportunities

Undoubtedly Islamic Revolution of Iran has been the source of Islamic awakening in the middle-east. Therefore Islamic Republic of Iran plays the role of an example and a director of political developments in the region. Islamic awakening in Arab countries has been able to question the dominant discourse of dictators in the middle-east region and topple their regimes. These developments include ...

Computational modeling under uncertainty: challenges and opportunities

Computational Biology has increasingly become an important tool for biomedical and translational research. In particular, when generating novel hypothesis despite fundamental uncertainties in data and mechanistic understanding of biological processes underpinning diseases. While in the present book, we have reviewed the necessary background and existing novel methodologies that set the basis fo...

Cardiovascular transcriptomics and epigenomics using next-generation sequencing: challenges, progress, and opportunities.